DIFFERENTIAL EXPRESSION OF INTERLEUKIN-6, INTRACELLULAR ADHESION MOLECULE-1, AND MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MOLECULES IN RENAL-CARCINOMA CELLS STIMULATED WITH S FIMBRIAE OF UROPATHOGENIC ESCHERICHIA-COLI

The production of interleukin-6, intracellular adhesion molecule 1, an d major histocompatibility complex class II molecules by a renal carci noma cell line (ACHN) in response to S fimbriae of uropathogenic Esche richia coli was studied. S fimbriae adhered to ACHN cells and stimulat ed the production of interleukin-6 and intercellular adhesion molecule 1 but did not affect major histocompatibility complex class II expres sion by renal carcinoma cells. Our data demonstrate that S fimbriae of E. coli display immunomodulating properties on kidney-derived epithel ial cells.