MAPPING OF A NOVEL GENE FOR FAMILIAL HYPERTROPHIC CARDIOMYOPATHY TO CHROMOSOME-11

Familial hypertrophic cardiomyopathy (FHC) is a cardiac disorder trans mitted as an autosomal dominant trait. FHC has been shown to be geneti cally heterogeneous with less than 50% of published pedigrees being as sociated with mutations in the beta myosin heavy chain (beta-MHC) gene on chromosome 14q11-q12. A second locus has recently been reported on chromosome 1. We examined the segregation of microsatellite markers i n a French pedigree for which the disease is not linked to beta-MHC ge ne. We found significant linkage of the disease locus to several (CA)n repeats located on chromosome 11 (lod scores between +3.3 and +4.98). The data suggest the localization of the novel FHC gene in a region s panning 17 centiMorgans.