DIMETHYL 3,3'-(4-METHYL-1,3-NAPHTHYLENE)DIPROPIONATE AS A SINGLET OXYGEN TRAP IN BIOLOGICAL-SYSTEMS

Authors
MULLER K ZIEREIS K
Citation
K. Muller et K. Ziereis, DIMETHYL 3,3'-(4-METHYL-1,3-NAPHTHYLENE)DIPROPIONATE AS A SINGLET OXYGEN TRAP IN BIOLOGICAL-SYSTEMS, Archiv der pharmazie, 326(6), 1993, pp. 369-371
Citations number
16
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
326
Issue
6
Year of publication
1993
Pages
369 - 371
Database
ISI
SICI code
0365-6233(1993)326:6<369:D3AASO>2.0.ZU;2-L
Abstract
The utility of dimethyl 3,3'-(4-methyl-1,3-naphthylene)dipropionate (D MNDP) as a singlet oxygen trap in biological systems is described. The determination of the rate constant for the reaction of DMNDP with sin glet oxygen in acetonitrile gave a value of 9.8 - 10(-7) M-1s-1; the h alf-life of the corresponding endoperoxide at 37-degrees-C in phosphat e buffered saline is 412 min. DMNDP does not possess sensitizing prope rties, and its usefulness for the detection of singlet oxygen is demon strated in the photooxidation of liposomes by 5,10,15,20-tetraphenyl-2 1H,23H-porphine (TPP).