CAPTOPRIL ATTENUATES PACING-INDUCED ACUTE HEART-FAILURE BY INCREASINGTOTAL VASCULAR CAPACITANCE

To study the effects of captopril pretreatment on vascular capacitance in acute heart failure, anesthetized splenectomized dogs were subject ed to rapid right ventricular pacing (RRVP) at 250 beats/min for 60 mi n combined with an intravenous (i.v.) 20-ml/kg volume load of dextran 70 over 10 min. Captopril pretreatment [50 mg every 8 h for 3 days plu s 0.5 mg/kg intravenously (i.v.) at induction of anesthesia] attenuate d development of acute heart failure associated with RRVP, maintaining normal cardiac output (CO) and pulmonary capillary wedge pressures (P CWP). Total vascular capacitance after a volume load plus RRVP was hig her in captopril-pretreated animals (129.8 +/- 3.2 vs. 100.4 +/- 4.8 m l/kg) owing to an increase in unstressed volume (118.6 +/- 3.1 vs. 88. 4 +/- 5.6 ml/kg). Arterial capacity and pulmonary (central) vascular c apacitance were also increased.