Rh. Mattson et Rw. Rebar, CONTRACEPTIVE METHODS FOR WOMEN WITH NEUROLOGIC DISORDERS, American journal of obstetrics and gynecology, 168(6), 1993, pp. 2027-2032
Sex steroids in oral contraceptives exert several effects on the centr
al nervous system and are therefore of concern when used by neurologic
ally compromised women. In general, oral contraceptives do not aggrava
te epileptic seizures and are not contraindicated in cases of tension
headache. Oral contraceptives can be used in cases of migraine without
focal neurologic symptoms as long as headache symptoms do not worsen.
Levels of sex steroids can be diminished through enzyme induction by
antiepileptic drugs, giving rise to the possibility of contraceptive f
ailure and exposure of the fetus to the teratogenic properties of anti
seizure medications. Women with common migraine (without focal neurolo
gic symptoms) who are taking oral contraceptives should be monitored f
or possible exacerbation of their symptoms. Women who do experience wo
rsening of headache symptomatology when taking the pill should conside
r alternate means of contraception.