THE EXPRESSION OF APHIDICOLIN-INDUCED FRAGILE SITES IN FAMILIAL BREAST-CANCER PATIENTS

Authors
MITCHELL ELD WOODHOUSE B BIRCH JM SANTIBANEZKOREF MF
Citation
Eld. Mitchell et al., THE EXPRESSION OF APHIDICOLIN-INDUCED FRAGILE SITES IN FAMILIAL BREAST-CANCER PATIENTS, Cancer genetics and cytogenetics, 67(2), 1993, pp. 108-112
Citations number
25
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
67
Issue
2
Year of publication
1993
Pages
108 - 112
Database
ISI
SICI code
0165-4608(1993)67:2<108:TEOAFS>2.0.ZU;2-5
Abstract
The expression frequency of aphidicolin-induced fragile sites was exam ined in familial breast cancer patients to determine whether this para meter could be used as a marker of genetic susceptibility in at-risk i ndividuals. No difference was found in expression frequency between th e breast cancer patients and a group of normal individuals (p = 0.61). This indicates that the expression frequency of aphidicolin-induced f ragile sites is not a suitable marker for assessing genetic susceptibi lity in familial breast cancer.