EXPRESSION OF APHIDICOLIN-INDUCED FRAGILE SITES IN LYMPHOCYTES OF PATIENTS WITH BREAST-CANCER

Authors
ARDISIA C VENTI G COLOZZA MA BRESCHI C PORFIRIO B DAVIS S TONATO M DONTI E
Citation
C. Ardisia et al., EXPRESSION OF APHIDICOLIN-INDUCED FRAGILE SITES IN LYMPHOCYTES OF PATIENTS WITH BREAST-CANCER, Cancer genetics and cytogenetics, 67(2), 1993, pp. 113-116
Citations number
34
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
67
Issue
2
Year of publication
1993
Pages
113 - 116
Database
ISI
SICI code
0165-4608(1993)67:2<113:EOAFSI>2.0.ZU;2-8
Abstract
The expression of fragile sites induced by aphidicolin (APC) was evalu ated on metaphase chromosomes obtained from the peripheral blood lymph ocytes of 26 women with breast cancer and 15 sex- and age-matched norm al controls. Both the proportion of damaged cells (P < 0.001) and the mean number of gaps and breaks per cell (0.02 < P < 0.05) were signifi cantly higher in the patient group. There were no differences in eithe r the age-related fragile site levels or the expression of single frag ile sites between patients and controls. Our findings indicate an incr eased genetic instability in women with breast carcinoma.