UNIVARIATE AND MULTIVARIATE-ANALYSIS OF 8 INDICATIONS FOR POSTOPERATIVE RADIOTHERAPY AND THEIR SIGNIFICANCE FOR LOCAL-REGIONAL CURE IN ADVANCED HEAD AND NECK-CANCER
La. Ravasz et al., UNIVARIATE AND MULTIVARIATE-ANALYSIS OF 8 INDICATIONS FOR POSTOPERATIVE RADIOTHERAPY AND THEIR SIGNIFICANCE FOR LOCAL-REGIONAL CURE IN ADVANCED HEAD AND NECK-CANCER, Journal of Laryngology and Otology, 107(5), 1993, pp. 437-440
Eighty consecutive patients with advanced head and neck cancer were tr
eated with combined therapy of radical surgery and post-operative radi
otherapy. Indications for post-operative radiotherapy were pathologica
l staging of the primary tumour (pT3 or pT4), poorly differentiated or
undifferentiated carcinoma (G3, G4), tumour thickness, tumour invasio
n in the surrounding tissues with slender tumour strands and solitary
tumour cells, perineural spread, lymphangio-invasive tumour growth, mu
ltiple positive neck nodes or extranodal spread, and microscopical irr
adicality of the surgical margins. The contribution for prognosis of t
hese indications for post-operative radiotherapy were retrospectively
calculated in an univariate and multivariate analysis. Of all investig
ated parameters, the mode of tumour invasion and lymphangio-invasive g
rowth were independent prognostic factors. If these unfavourable progn
ostic signs are present, post-operative radiotherapy has to be intensi
fied to at least curative doses of 66 Gy or more to the areas at risk.