Two novel C19-skeleton quassinoids, one with a lactonic linkage at C-7
and another with a lactonic linkage at C-12, and seven novel highly o
xygenated quassinoids with a C20-skeleton were isolated from the leave
s of Eurycoma longifolia. Their structures and stereochemistry were es
tablished by spectroscopic data, including two-dimensional NMR techniq
ues, and X-ray analysis. The relationships between their structures an
d cytotoxicities are also discussed.