INHIBITION OF PROGESTERONE ACTION BY A FACTOR IN HUMAN FOLLICULAR-FLUID

Authors
JUNEJA R KADAM P KADAM AL KOIDE SS
Citation
R. Juneja et al., INHIBITION OF PROGESTERONE ACTION BY A FACTOR IN HUMAN FOLLICULAR-FLUID, Hormone and Metabolic Research, 25(6), 1993, pp. 298-300
Citations number
20
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Hormone and Metabolic Research → ACNP
ISSN journal
00185043
Volume
25
Issue
6
Year of publication
1993
Pages
298 - 300
Database
ISI
SICI code
0018-5043(1993)25:6<298:IOPABA>2.0.ZU;2-K
Abstract
A factor was found in human follicular fluid that blocked progesterone -stimulated net uptake Ca-45(2+) in human sperm and progesterone-induc ed maturation of Xenopus oocyte. The factor was partially purified by ultrafiltration through PM-10 membrane and gel filtration on Sephadex G-25 column. The active fraction is effective at a concentration of 20 0 mug/ml. The present findings suggest that hFF factor may regulate th e metabolism of progesterone sensitive cells.