AMELIORATIVE CAPACITIES OF VITAMINS AND MONOTHIOLS ADMINISTERED ALONEOR IN COMBINATIONS IN METHYLMERCURY MOBILIZATION IN NERVOUS AND NONNERVOUS TISSUES OF MICE

The extent of mercury mobilisation was recorded from various tissues ( brain, spinal cord, liver and kidney) of male mice administered with a daily dose of methylmercury chloride (1 mg/kg) for seven days. For th is purpose 10 groups of animals were intoxicated. Out of these, one gr oup was sacrificed on 8th day and one group was kept without toxicant for another seven days before sacrificing on 15th day. To the rest of the groups were given a daily dose of N-acetyl-DL-homocysteine thiolac tone (NAHT), glutathione (GSH), vitamin B Complex and E, applied eithe r alone or in combinations. All these animals were sacrificed on the 1 5th day. The mercury clearance rate during thiols, vitamins and their co-administration was examined. Study shows that both the vitamins wer e able to increase mercury elimination from the nervous and non-nervou s tissues. Their combination with NAHT was not suitable as mercury lev el was increased in all the tissues except kidney as compared to NAHT alone treated group. However, vitamin B Complex combination with gluta thione was much advantageous. It is concluded from the overall study t hat application of vitamin B Complex and E either alone or in combinat ion with GSH is quite suitable for methylmercury post-therapy.