METAL-COMPLEXES OF THE ANTIINFLAMMATORY DRUG SODIUM [2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL]ACETATE (DICLOFENAC SODIUM) - MOLECULAR AND CRYSTAL-STRUCTURE OF CADMIUM DICLOFENAC

The reactions of ZnCl2, CdCl2 and Hg(NO3)2.H2O with deprotonated diclo fenac (L) were studied in aqueous solutions. Complexes of the formulae [Zn(L)2(H2O)], [Cd(L)2(H2O)], [HgL2] and [Cd2(H2O)(C2H5OH)2(L)4]n wer e isolated and characterized as solid products by elemental analyses a nd spectral (IR, H-1 NMR) and thermal studies. The crystal structure o f the complex [Cd2(H2O)(C2H5OH)2L4]n was also solved. The central feat ure of the macromolecule is a dinuclear moiety. Distorted octahedral c oordination at Cd(1) is completed by oxygen atoms from one molecule of water, two molecules Of C2H5OH, two oxygen atoms from one chelating l igand with a monoatomic bridging oxygen that bridges the atoms Cd(2)-C d(I) = 4.490(1) angstrom and one oxygen from a bidentate bridging carb oxylato group that bridges the atoms Cd(1)-Cd(2) = 4.300(1) angstrom. The geometry at Cd(2) is that of a distorted square pyramid with oxyge n atoms from one chelating and one munodentate carboxylato group and t he monoatomic bridging oxygen atom occupying equatorial positions. The apical site of the square pyramid is occupied by the oxygen atom of t he bidentate bridging carboxylato group. The crystal structure of the diclofenac acid is also reported.