REASSIGNMENT OF HUMAN RENIN GENE TO CHROMOSOME-1Q32 IN STUDIES OF A (1 4)(Q42 P16) TRANSLOCATION

The human renin gene (REN) has been assigned to chromosome 1q42. Linka ge studies are, however, inconsistent with this localization. We there fore reexamined the question of the location of REN using a patient wh ose distal chromosome 1q arm was translocated to chromosome 4 [(1;4)(q 42;p16)]. In situ hybridization using a H-3-labelled REN probe demonst rated hybridization signals confined to the q32 band of chromosome 1, with radioactivity in the translocated 1q42 region being similar to th e low levels along all other chromosomes.