HYDROGELS OBTAINED BY RADIATION-INDUCED POLYMERIZATION AS DELIVERY SYSTEMS FOR PEPTIDE AND PROTEIN DRUGS

Authors
CARENZA M LORA S CALICETI P SCHIAVON O VERONESE FM
Citation
M. Carenza et al., HYDROGELS OBTAINED BY RADIATION-INDUCED POLYMERIZATION AS DELIVERY SYSTEMS FOR PEPTIDE AND PROTEIN DRUGS, Radiation physics and chemistry, 42(4-6), 1993, pp. 897-901
Citations number
9
Categorie Soggetti
Nuclear Sciences & Tecnology","Chemistry Physical","Physics, Atomic, Molecular & Chemical
Journal title
Radiation physics and chemistry → ACNP
ISSN journal
0969806X
Volume
42
Issue
4-6
Year of publication
1993
Pages
897 - 901
Database
ISI
SICI code
0969-806X(1993)42:4-6<897:HOBRPA>2.0.ZU;2-T
Abstract
The controlled release of peptides and proteins from hydrogels obtaine d by radiation-induced polymerization of 2-hydroxyethyl methacrylate a t a low temperature was studied. It was found that the extent of relea se progressively decreased as protein molecular weight increased until no further release occurred above a critical value of the latter. How ever, an increasing rate of protein release was found if the polymeriz ation was carried out in the presence of poly(ethylene glycol), PEG. M oreover, only with high molecular weight PEGs were large proteins rele ased. The release data as a function of swellability and porosity of p olymer matrices were discussed.