STUDY ON SLOW-RELEASE ANTICANCER DRUGS PREPARED BY RADIATION-INDUCED POLYMERIZATION

This paper reports the research results which the anticancer drugs Ara -C with controlled slow release were made by radiation induced polymer ization of monomers such as methacrylates at room temperature. Our stu dies showed that not only hydrophilic synthetic polymers but also hydr ophobic polymers such as hydrophobic methacrylates (including MMA, EMA , and BMA) could be used to the immobilization. In vitro the rate of d rugs release was controlled by the many factors such as the content of drugs, the monomer material, the crosslinking agent, the irradiation dose and the water content, etc.