H. Lettau et al., SYNTHESIS OF LIPOXYGENASE INHIBITORS .2. SYNTHESIS OF LACTAMARYLHYDRAZONES AND TETRAHYDROAZEPINOCHINAZOLINON-ARYLHYDRAZONES, Die Pharmazie, 48(6), 1993, pp. 410-414
The synthesis of lactamarylhydrazones as cyclic amidrazones is describ
ed starting from 5-, 6- and 7-membered lactames. Tetrahydroazepinochin
azolinon-arylhydrazones were prepared from caprolactam. The compounds
were tested against soja lipoxygenase. A few compounds were very stron
g inhibitors (IC50 value up to 4 . 10(-9) mol/l).