SYNTHESIS OF LIPOXYGENASE INHIBITORS .2. SYNTHESIS OF LACTAMARYLHYDRAZONES AND TETRAHYDROAZEPINOCHINAZOLINON-ARYLHYDRAZONES

Citation
H. Lettau et al., SYNTHESIS OF LIPOXYGENASE INHIBITORS .2. SYNTHESIS OF LACTAMARYLHYDRAZONES AND TETRAHYDROAZEPINOCHINAZOLINON-ARYLHYDRAZONES, Die Pharmazie, 48(6), 1993, pp. 410-414
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00317144
Volume
48
Issue
6
Year of publication
1993
Pages
410 - 414
Database
ISI
SICI code
0031-7144(1993)48:6<410:SOLI.S>2.0.ZU;2-H
Abstract
The synthesis of lactamarylhydrazones as cyclic amidrazones is describ ed starting from 5-, 6- and 7-membered lactames. Tetrahydroazepinochin azolinon-arylhydrazones were prepared from caprolactam. The compounds were tested against soja lipoxygenase. A few compounds were very stron g inhibitors (IC50 value up to 4 . 10(-9) mol/l).