Dural sinus thrombosis in the newborn period is a rare but underrecogn
ized condition which may cause seizures, macrocephaly, lethargy, and r
espiratory depression. A 10-day-old term infant with no pre- or perina
tal risk factors for thrombosis presented with seizures and was found
to have dural sinus thrombosis on computed tomography and magnetic res
onance imaging (MRI). One week later, MRI revealed partial resolution
and 3 weeks later disclosed a complete resolution of the thrombosis. C
linicians should consider the diagnosis of neonatal dural sinus thromb
osis in infants presenting with seizures and/or increased intracranial
pressure even in the absence of risk factors or when the cranial comp
uted tomography is normal. MRI is the most sensitive diagnostic tool t
o establish the diagnosis and permit a noninvasive follow-up, contribu
ting to our understanding of the natural history, associated pathology
, and prognosis of this condition.