HEMATOLOGICAL MODIFICATIONS OBSERVED DURI NG VIRAL HEMORRHAGIC-DISEASE (VHD) IN THE RABBIT

The results concerning haematological modifications in thirty rabbits innoculated with the V.H.D. virus are presented. The earliest abnormal ities (within hte first 24hr) are lymphopenia and/or the appearance of soluble complexes. Lymphopenia is frequent after the 30th hour. Some animals also exhibited neutropenia (probably of peripheral origin) and regenerative anaemia (by haemorrhage). Some rabbits show straight awa y a disseminated intravascular coagulation (D.C.I.) and a hepatocellul ar insufficiency. Together these are rapidly fatal. Others show first of all an isolated D.C.I. and survive longer. Hyperfibrinolysis appear ed to be more easily shown by the D-Di and the FS tests than the Spli- test.