THE ROLE OF PITUITARY-ADRENAL SYSTEM IN P ATHOGENESIS OF THE THYMIC ENDOCRINE FUNCTION DISORDERS IN PATIENTS WITH THYMOMAS

Authors
GRINEVICH YA BENDYUG GD YUGRINOVA LC LABUNETS IF BOBRO LI BOLGOVA LS KIREYEVA ES
Citation
Ya. Grinevich et al., THE ROLE OF PITUITARY-ADRENAL SYSTEM IN P ATHOGENESIS OF THE THYMIC ENDOCRINE FUNCTION DISORDERS IN PATIENTS WITH THYMOMAS, Eksperimental'naa onkologia, 15(3), 1993, pp. 61-63
Citations number
14
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
15
Issue
3
Year of publication
1993
Pages
61 - 63
Database
ISI
SICI code
0204-3564(1993)15:3<61:TROPSI>2.0.ZU;2-E
Abstract
The endocrine function of the thymic gland and pituitary-adrenal syste m has been studied in 53 patients with malignant thymomas and 85 healt hy individuals aged 20 to 50 years. The increased blood serum levels o f ACTH and cortisole in thymomas results in a decreased hormonal activ ity of the thymus, which can be accompanied by disruption in the perip heral chain of the immune system and disorders in formation of immune responses. It has been shown experimentally that ionol, epithalamine a nd tactivine inhibit the development of lymphomas in AKR mice.