THE IN-VITRO STUDY OF CISPLATIN EFFECT ON RESPIRATION OF HEPATOCYTE MITOCHONDRIA OF INTACT RATS

Authors
TODOR IN CHEKHUN VF
Citation
In. Todor et Vf. Chekhun, THE IN-VITRO STUDY OF CISPLATIN EFFECT ON RESPIRATION OF HEPATOCYTE MITOCHONDRIA OF INTACT RATS, Eksperimental'naa onkologia, 15(3), 1993, pp. 72-74
Citations number
9
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
15
Issue
3
Year of publication
1993
Pages
72 - 74
Database
ISI
SICI code
0204-3564(1993)15:3<72:TISOCE>2.0.ZU;2-R
Abstract
Negative influence of 0.015 mM cisplatin in vitro on the function of m itochondria respiratory chain in the rat liver was found. The preparat ion increased the rate of oxygen consumption by mitochondria in state 4, decreased the same parameter in state 3, reducing the respiratory c ontrol index and ADP/O ratio. The effect was more expressed in the pre sence of succinate than in case of glutamate oxidation. Combined admin istration of 2,4-dinitrophenol and cisplatin activized mitochondria re spiration to a less extent than without cisplatin.