Ultrastructural changes of the germinal vesicle during the growth of r
abbit oocytes were studied by means of light and electron microscopy,
H-3-uridine autoradiography, Ag-NOR staining and E-PTA staining. Parti
cular interest was paid to the nucleolo-genesis and condensation of ch
romatin. In contrast to other mammalian species, chromosome condensati
on in rabbit oocytes occurred concomitantly with rRNA synthesis-depend
ent nucleolar compaction and preceded nuclear envelope breakdown and r
esumption of meiosis.