EFFECT OF PERCUTANEOUS BALLOON MITRAL VALVULOPLASTY ON SERUM CREATININE PHOSPHOKINASE MB-ISOENZYME LEVELS

Twenty-one patients with moderate to severe mitral stenosis were treat ed with percutaneous balloon mitral valvuloplasty (PBMV) using Inoue m itral double-lumen balloon catheters. Creatinine phosphokinase MB isoe nzyme (CPK-MB) levels were measured at baseline, 5 min, 6 h, and 18 h post dilatation. Haemodynamic indexes, 12-lead ECGs, and 2-dimensional echocardiograms were performed to evaluate systolic function postproc edure. CPK-MB levels were modestly increased at 5 min and at 6 h postp rocedure compared with the baseline level (p < 0.001) but were still w ithin the normal reference range, except for one patient who had a lev el at 5 min minimally above the upper limit of normal. CPK-MB levels w ere not significantly increased at 18 h after the procedure. No signif icant changes in ejection fractions, 12-lead ECGs, and regional wall m otion occurred in any of the patients studied. In conclusion, PBMV cau ses modest early elevation of CPK-MB. This elevation is not associated with changes in LV systolic function and does not interfere with the diagnosis of acute myocardial infarction using the enzyme elevation cr iteria. (C) 1993 Wiley-Liss, Inc.