THEORY FOR CHARACTERIZATION OF HIPPOCAMPAL LONG-TERM POTENTIATION INDUCED BY TIME-STRUCTURED STIMULI

We theoretically investigate long-term potentiation (LTP) in the hippo campus using a simple model of a neuron stimulated by three different time-structured input signals (regular, Markov, and chaotic). The syna ptic efficacy change is described taking into account both N-methyl-D- aspartate (NMDA) and non-NMDA receptors. The experimental results are successfully explained by our neuron model, and the remarkable fact th at the chaotic stimuli in the nonstationary regime produce the largest LTP is discussed.