Pwf. Fischer et al., MAGNESIUM STATUS AND EXCRETION IN AGE-MATCHED SUBJECTS WITH NORMAL AND ELEVATED BLOOD PRESSURES, Clinical biochemistry, 26(3), 1993, pp. 207-211
Plasma, erythrocyte, and leucocyte magnesium (Mg) concentration, as we
ll as urinary Mg, calcium (Ca), and phosphorus (P) excretion were dete
rmined in male subjects with elevated diastolic blood pressure (DBP) >
90 mmHg. These parameters were compared to those in normotensive age-m
atched (DBP < 85 mmHg) and drug-treated hypertensive subjects. Mg and
Ca were determined by atomic absorption spectroscopy and P was determi
ned by a colorimetric method. Urinary excretion was expressed in terms
of creatinine (Cr) excretion. There were no significant differences i
n plasma, erythrocyte, or leucocyte Mg concentrations. Both urinary Ca
and Mg were significantly decreased in the group with elevated blood
pressure (BP) and the drug-treated group compared to the normotensive
group. Urinary P was elevated in the drug-treated hypertensive group.
Of all the variables studied, urinary Mg was the only one that was sig
nificantly inversely correlated with both systolic (SBP) and DBP. Thes
e data suggest that decreased urinary Mg, which may be indicative of a
decreased Mg intake, is associated with hypertension.