PREPARATION FOR MARROW TRANSPLANTATION IN HODGKINS AND NON-HODGKINS-LYMPHOMA USING BU CY/

The results of autologous and allogeneic BMT in 44 patients with Hodgk in's or non-Hodgkin's lymphomas who received preparative therapy consi sting of busulfan 16 mg/kg and cyclophosphamide 120 mg/kg are presente d. Sixteen patients are surviving free of disease between 8 months and 6 years after transplantation. Thirteen patients either did not attai n complete remission or experienced a recurrence of their disease. Fif teen patients died from treatment-related complications. Karnofsky sco re less-than-or-equal-to 70, lactate dehydrogenase greater than twice normal and the development of hepatic veno-occusive disease were assoc iated with failure to achieve lymphoma-free survival.