S. Gherini et al., DELAYED WOUND-HEALING AND NUTRITIONAL DEFICIENCIES AFTER TOTAL HIP-ARTHROPLASTY, Clinical orthopaedics and related research, (293), 1993, pp. 188-195
Ninety-two patients (103 hips) treated with total hip arthroplasty (TH
A) were assessed before and after operation to determine nutritional s
tatus and any correlation with delayed wound healing. Parameters indic
ative of nutritional status (serum albumin and serum transferrin) were
assessed, along with immunologic and anthropometric parameters. Delay
ed wound healing complicated 34 of the 103 (33%) THAs. The preoperativ
e serum transferrin levels were significantly lower for patients who s
ubsequently developed wound-healing complications. Patients treated wi
th single-stage, bilateral procedures had substantially lower postoper
ative serum transferrin and serum albumin levels and significantly hig
her incidences of delayed wound healing (64%) than patients who had si
ngle joint procedures (25%). Only preoperative serum transferrin level
s showed significant value in predicting which patients would have del
ayed wound healing. None of the other serologic variables, including s
erum albumin and total lymphocyte count, proved to be a predictor of d
elayed wound healing. The preoperative assessment of three variables-s
erum transferrin value, bilateral procedure, and patient age-resulted
in the correct prediction of wound healing outcome in 79% of the patie
nts. This preoperative information, in combination with postoperative
monitoring of serum transferrin and albumin levels, should alert the p
hysician to the approach of a malnourished state. The malnourishment i
s attributable to heightened demands on the body's basal energy requir
ements after major orthopaedic surgery and can increase morbidity and
prolong the hospital stay.