S. Ito et al., EFFECTS OF FENVALERATE AND ESFENVALERATE ON HEPATIC GAP JUNCTIONAL INTERCELLULAR COMMUNICATION IN RATS, Cell biology and toxicology, 9(2), 1993, pp. 189-196
Effects of in vivo exposure with fenvalerate, esfenvalerate and DDT on
hepatic gap junctional intercellular communication (GJIC) in Sprague-
Dawley (SD) rats were examined by in vivo/in vitro dye-transfer assay
and by immunohistochemical staining of connexin 32 (Cx32, major liver
gap junction protein). Fenvalerate (75 mg/kg/day), esfenvalerate (25 m
g/kg/day), DDT (50 mg/kg/day) and corn oil (vehicle control, 5 ml/kg/d
ay) were administered orally once a day. Animals were killed at weeks
1, 2, 4 and 6 after starting the experiment. In the fenvalerate- and e
sfenvalerate-groups, no compound-related changes in GJIC and Cx32 expr
ession were observed. On the contrary, in the DDT-group, average sizes
of the dye spread after injection of Lucifer Yellow decreased at week
s 1, 2 and 4, and the area per GJ spot shown by Cx32-immunohistochemic
al staining decreased at weeks 4 and 6. It is concluded that neither f
envalerate nor esfenvalerate inhibits hepatic GJIC with in vivo exposu
re.