DEPOSITION OF ALUMINUM IN BRAIN-TISSUES OF RATS EXPOSED TO INHALATIONOF ALUMINUM ACETYLACETONATE

THE present paper reports data concerning aluminium accumulation and c ompartmentation in the central nervous system from rats exposed by inh alation to aluminium acetylacetonate [Al(acac)3] for two weeks. The co mplex Al(aca)3 was chosen for being neutral, hydrolytically stable and lipophilic. After animals treatment, Al(III) was identified fluorimet rically by using morin (3,5,7',2',4'-pentahydroxyflavone) that gives a specific green-yellow fluorescence when complexed to the metal. Al(II I) was observed to be accumulated in the brain cortex, hippocampus, en thorinal area, olfactory bulb as well as in the Purkinje cells of cere bellum, and in the white matter.