SYNTHESIS OF PYRIDINE-DERIVATIVES BY REACTIONS OF ALPHA, BETA-UNSATURATED NITRILES WITH 2-OXO-CYCLOALKANO CARBOTHIOIC ACID ANILIDES

Authors
BOGDANOWICZSZWED K KRASODOMSKA M LIPOWSKA M RYS B SKONECKA A
Citation
K. Bogdanowiczszwed et al., SYNTHESIS OF PYRIDINE-DERIVATIVES BY REACTIONS OF ALPHA, BETA-UNSATURATED NITRILES WITH 2-OXO-CYCLOALKANO CARBOTHIOIC ACID ANILIDES, Monatshefte fuer Chemie, 124(6-7), 1993, pp. 721-731
Citations number
18
Categorie Soggetti
Chemistry
Journal title
Monatshefte fuer Chemie → ACNP
ISSN journal
00269247
Volume
124
Issue
6-7
Year of publication
1993
Pages
721 - 731
Database
ISI
SICI code
0026-9247(1993)124:6-7<721:SOPBRO>2.0.ZU;2-E
Abstract
The tandem Michael addition-cyclization of 2-oxo-cycloalkane carbothio ic acid anilides 1-3 to benzylidenemalononitrile 4 yielded spiroannula ted pyridines 5-7. Reaction of acrylonitrile with 2 and 3 gave 2,2-dis ubstituted Michael adducts 14, 15, whereas with 1 led to 2,2,5-tri(2-c yanoethyl)-cyclopentanone 11.