The mechanism of formation of extracellular fluid is first described,
followed by an explanation of the relation between osmotic force, refl
ection coefficient and molecular size. The possible mechanism of brain
extracellular fluid formation is then proposed in relation to the res
triction offered by the blood-brain barrier. The functions and composi
tions of cerebrospinal fluid (CSF) are then described followed by sect
ions on the process of formation of CSF, the non-electrolytes and prot
eins in CSF, the drainage mechanisms and protein synthesis by the chor
oid plexus.