Background: Assisted reproductive technologies are making it possible
for women to conceive when it was otherwise impossible. One of the sid
e effects is multiple gestations. This may be especially disadvantageo
us when it occurs within an anomalous uterus. Patient and Methods: A 3
6-year-old women with the help of gamete intrafallopean transfer conce
ived triplets in a uterus didelphys. This pregnancy was further compli
cated by anencephaly of one of the triplets. The patient was managed b
y a combination of chorionic villi sampling and selective reduction th
at ended with the successful delivery of a term infant. Conclusion: Pr
egnancy reduction can be safely performed in a twin pregnancy on one s
ide of a uterus didelphys. More reports will be required to determine
whether this is the most optimal choice.