COORDINATION PROPERTIES OF 6-DEOXY-6-[1-(2-AMINO) ETHYLAMINO]-BETA-CYCLODEXTRIN AND THE ABILITY OF ITS COPPER(II) COMPLEX TO RECOGNIZE AND SEPARATE AMINO-ACID ENANTIOMERIC PAIRS

The functionalized cyclodextrin -deoxy-6-[1-(2-amino)ethylamino]-beta- cyclodextrin was synthesized, and an NMR, EPR, pH-metric, and calorime tric investigation was carried out in aqueous solution in order to asc ertain its behaviour towards protonation and copper(II) complex format ion. The thermodynamic parameters of the ternary complex formation wit h alanine, phenylalanine and tryptophan enantiomeric pairs were also d etermined (25-degrees-C and I = 0.1 mol dm- 3). No thermodynamic enant ioselectivity was observed in these systems, while a chiral, though po or, discrimination was observed in LEC: c.d. spectra also show enantio meric stereoselectivity. The results of the present investigation, com pared with previously reported results, suggest the occurrence of a ci s-complex reversible trans-complex equilibrium in such systems.