RELATIONSHIP BETWEEN TISSUE CALCIUM CONTENT AND DUODENAL-ULCER IN THERAT

Since the effect of cellular calcium on cell injury has been in questi on, this study focused on the relationship between tissue calcium cont ent and cysteamine-induced duodenal ulcer. Rats treated with cysteamin e showed a high frequency and severity of duodenal ulcer, and the calc ium content in the duodenal mucosa was elevated Furthermore, the level of calcium content in duodenal mucosa was positively associated with the severity of the duodenal lesion. Whereas administration of calcium increased duodenal ulcerative response to cysteamine, verapamil affor ded protection against ulceration. We conclude that calcium accumulati on in duodenal mucosa is related to duodenal ulceration induced by cys teamine.