CENTRAL OBESITY - RELATIONSHIP BETWEEN CO NICITY INDEX AND LIPOPROTEIC PARAMETERS AS RISK-FACTORS FOR CORONARY ATHEROSCLEROSIS

In middle age men the relationship between biochemical and anthropomet ric parameters was studied associated with central obesity in order to evaluate the risk of coronary atherosclerosis. In 31 males of 30 to 6 5 years of age, <<apparently healthy>>, we determined the percentil 50 (P50) for body fat percentage (PG), 26.8% (utilizing the skinfold tic knesses) and P75 of Conicity Index (IC), 1.26. Were selected 63 subjec ts with different values of PG and IC. IC, adjusted for BMI and PG, co rrelated with Cholesterol (CT), Triglycerides (TG), CT/C-HDL, C-LDL/C- HDL, Apolipoprotein B (ApoB), Apo B/C-HDL, (P < 0.01) in all cases), a nd cholesterol LDL (C-LDL) (P < 0.05). This population was divided in three groups: Group I, Control, N = 19, PG < = 27% and IC < 1.26; Grou p II, obese without Central Obesity Predominance (POC), N = 15, PG les s than or equal to 27% and IC less than or equal to 1.26; Group III, N = 23, obese with POC, PG > 27% and IC less than or equal to 1.26. We found that Group III vs Group II had: CT 242 +/- 35 vs 205 +/- 40 mg/d l (P < 0.01), C-LDL 165 +/- 41 vs 138 +/- 36 mg/dl (P < 0.05) and CT/C -HDL 6.0 +/- 1.2 VS 5.1 +/- 1.2 (p < 0.05) respectively. Group III vs I showed significant differences for all biochemical parameters and in dex studied with exception of C-HDL. In subjects with IC > 1.26 vs IC < = 1.26 increased the frequency of coronary risk factors and indicato rs: CT greater than or equal to 240 mg/dl, 59% vs 12% (P < 0.001); C-L DL greater than or equal to 160 mg/dl, 55% vs 18% (P < 0.001); Apo B> 120 mg/dl, 72% vs 26% (P < 0.001); CT/C-HDL > 4.5, 86% vs 53% (P < 0.0 1); C-LDL/C-HDL > 3.0, 86% vs 47% (P < 0.001); Apo B/C-HDL > 2.6, 72% vs 47% (P < 0.05). Our results suggest that the use of IC combined wit h lipoproteic factors and index will contribute to the detection of ma les at risk of coronary heart di-sease.