GALLOWAY-MOWAT SYNDROME OF ABNORMAL GYRAL PATTERNS AND GLOMERULOPATHY

The combination of microcephaly, gyral abnormalities, developmental de lay, and a glomerulopathy constitutes a recognizable syndrome. The inh eritance is autosomal recessive. Additional abnormalities may include seizures, minor facial anomalies, and hiatal hernia. Onset of proteinu ria often occurs in the first 3 months of life, but always before age 3 years. A uniform pattern of renal histologic changes has not been fo und. There is no effective treatment for the neurologic or renal manif estations of this condition. The prognosis is extremely poor; every pa tient but one has died before age 5 1/2 years. Antenatal diagnosis may be possible. (C) 1993 Wiley-Liss, Inc.