SYNTHESIS AND RECEPTOR-BINDING STUDIES OF 2-FUNCTIONALIZED 1,4-BENZODIAZEPINE DERIVATIVES AS POTENTIAL METACLAZEPAM-LIKE ANTIANXIETY AGENTS

Authors
ANZINI M CAPPELLI A VOMERO S CAGNOTTO A SKORUPSKA M
Citation
M. Anzini et al., SYNTHESIS AND RECEPTOR-BINDING STUDIES OF 2-FUNCTIONALIZED 1,4-BENZODIAZEPINE DERIVATIVES AS POTENTIAL METACLAZEPAM-LIKE ANTIANXIETY AGENTS, Il Farmaco, 48(7), 1993, pp. 897-905
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
7
Year of publication
1993
Pages
897 - 905
Database
ISI
SICI code
0014-827X(1993)48:7<897:SARSO2>2.0.ZU;2-S
Abstract
The synthesis of hoxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (2 ) is described. While the metaclazepam-like compound 2 showed an affin ity for benzodiazepine receptor central type (CBZRs) comparable to tha t of metaclazepam (1a), its intermediates bearing the exocyclic double bond resulted more active.