3,5-DIPHENYL-1H-PYRAZOLE DERIVATIVES .11. -PHENYL-4-(3,5-DIPHENYL-1-PYRAZOLYL)-3(5)-PYRAZOLE AMINES, 5-SUBSTITUTED -3-PHENYL-4(3,5-DIPHENYL-1-PYRAZOLYL)-1H-PYRAZOLES AND 2,6-DISUBSTITUTED O-4-PHENYL-5-(3,5-DIPHENYL-1-PYRAZOLYL)PYRIMIDINES WITH ANTIPYRETIC, ANTIINFLAMMATORY AND OTHER ACTIVITIES

Authors
BRUNO O RANISE A BONDAVALLI F SCHENONE P DAMICO M FILIPPELLI A FILIPPELLI W ROSSI F
Citation
O. Bruno et al., 3,5-DIPHENYL-1H-PYRAZOLE DERIVATIVES .11. -PHENYL-4-(3,5-DIPHENYL-1-PYRAZOLYL)-3(5)-PYRAZOLE AMINES, 5-SUBSTITUTED -3-PHENYL-4(3,5-DIPHENYL-1-PYRAZOLYL)-1H-PYRAZOLES AND 2,6-DISUBSTITUTED O-4-PHENYL-5-(3,5-DIPHENYL-1-PYRAZOLYL)PYRIMIDINES WITH ANTIPYRETIC, ANTIINFLAMMATORY AND OTHER ACTIVITIES, Il Farmaco, 48(7), 1993, pp. 949-966
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
7
Year of publication
1993
Pages
949 - 966
Database
ISI
SICI code
0014-827X(1993)48:7<949:3D.->2.0.ZU;2-G
Abstract
The synthesis of l-4-(3,5-diphenyl-1-pyrazolyl)-3(5)-pyrazoleamines 3 by reaction of some 2-(3,5-diphenyl-1-pyrazolyl)propanecarbothioamides with hydrazine is described. Also prepared were 3-phenyl-4-(3.5-diphe nyl-1-pyrazolyl)-1H-pyrazoles 6 and o-4-phenyl-5-(3,5-diphenyl-1-pyraz olyl)pyrimidines 7 by reaction of -phenyl-2-(3,5-diphenyl-1-pyrazolyl) -2-buten-1-one with hydrazine or guanidine and benzamidine, respective ly. Some compounds 3, 6 and 7 showed remarkable antipyretic, antiinfla mmatory and in vitro platelet antiaggregating activities, as well as w eak analgesic, antiarrhythmic, hypotensive and local anesthetic activi ties in rats and mice.