Benign large pineal cysts are rare lesions and sometimes difficult to
distinguish from neoplastic cysts of the pineal region. Seven patients
with cysts of the pineal region (1,5-2cm diameter), treated stereotac
tically were identified by retrospective chart review. In all patients
the cyst wall and contents were subjected to histopathological examin
ation. In 2 patients stereotactic operation showed that secondary (neo
plastic) cysts were ruled out. In 5 patients with symptomatic pineal c
ysts the stereotactic evacuation led to clinical recovery or marked im
provement (mean follow-up 20 months). The previous literature is revie
wed, aetiology, diagnostic work up and therapy discussed. We prefer th
e stereotactic management of cysts of the pineal region because it all
ows histological distinction of benign cysts from secondary cysts and
is a safe, minimal invasive procedure.