A 40-year-old man presented with a left optic neuropathy. Magnetic res
onance imaging demonstrated a contrast-enhancing mass along the course
of the left trigeminal nerve and in the region of the left cavernous
sinus with suprasellar extension. Preoperatively, he had a serum polyc
lonal gammopathy. Pathologic diagnosis was an intracranial plasma cell
granuloma. The patient responded to high-dose steroids with resolutio
n of his optic neuropathy, marked decrease in the size of the mass, an
d resolution of the serum polyclonal gammopathy. Intracranial plasma c
ell granuloma is a rare lesion; only 11 cases have been described in t
he literature. Almost half of the patients presented with vision loss
as their chief complaint.