CD4- HELP PREVENTS RAPID DELETION OF CD8+ CELLS AFTER A TRANSIENT-RESPONSE TO ANTIGEN(8)

Authors
KIRBERG J BRUNO L VONBOEHMER H
Citation
J. Kirberg et al., CD4- HELP PREVENTS RAPID DELETION OF CD8+ CELLS AFTER A TRANSIENT-RESPONSE TO ANTIGEN(8), European Journal of Immunology, 23(8), 1993, pp. 1963-1967
Citations number
25
Categorie Soggetti
Immunology
Journal title
European Journal of Immunology → ACNP
ISSN journal
00142980
Volume
23
Issue
8
Year of publication
1993
Pages
1963 - 1967
Database
ISI
SICI code
0014-2980(1993)23:8<1963:CHPRDO>2.0.ZU;2-P
Abstract
We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoieti c cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activat ion and that help, e.g. in the form of interleukin-2, can considerably delay the deletion. These experiments have implications for the desig n of protocols aiming at the establishment of specific immunological t olerance in T cells.