Animal welfare can be assessed in a precise way using measures of seve
ral kinds of abnormal behaviour, aversion, physiological responses inc
luding adrenal and opioid activity, immunosuppression, disease inciden
ce, weight gain, reproductive success and life expectancy. Welfare may
be affected in various ways in transgenic animals and animals treated
with biotechnology products. In order to assess this, carefully contr
olled studies using a wide range of welfare indicators are needed. The
se should be carried out for at least the total farm life of a breedin
g animal and for al least two generations. No such comprehensive studi
es of either category of animals have been reported in the scientific
literature to date although some measures of the effects of bovine som
atrophin have been made and are described. Neither the use of recombin
ant DNA products nor the keeping of transgenic animals should be permi
tted on commercial farms until it is clear that the welfare of these a
nimals is not adversely affected in comparison with that of animals wh
ich do not have the products administered to them or which are not pro
duced by transgenic procedures.