G. Magliulo et al., EXPERIMENTAL ENDOLYMPHATIC HYDROPS AND GLYCEROL - ELECTROPHYSIOLOGIC STUDY, The Annals of otology, rhinology & laryngology, 102(8), 1993, pp. 596-599
The object of the present study was to evaluate electrophysiologically
the therapeutic effect of glycerol on the cochlear function of guinea
pigs in which experimental hydrops had been surgically induced. Fifte
en albino guinea pigs were used. Each animal was chronically implanted
to follow the evolution of hearing. The experimental protocol conside
red 3 groups of guinea pigs (5 animals each). Group 1 received no drug
treatment, while groups 2 and 3 were given glycerol orally at 0.75 an
d 0.50 g/kg of body weight once a day for 4 months. The audiograms of
the animals treated with glycerol showed a statistically significant h
earing improvement compared with the control group. Clinically, our re
sults seem to support the view of those who favor the use of glycerol
for the medical treatment of Meniere's disease at an early stage.