CANINE PARVOVIRUS .1. PATHOGENESIS AND VACCINATION

Canine parvovirus is well known for its destruction of rapidly dividin g cells, such as those of the gastrointestinal epithelium, lymph nodes , and bone marrow. The resulting clinical syndrome of malaise, hemorrh agic diarrhea, dehydration, and septicemia can be devastating in puppi es. Puppies that are vaccinated may not be immunized because maternal antibodies may block the immune response to vaccination but are not pr otective. New vaccines have been developed that are more effective in generating an immune response in the face of maternal antibody interfe rence.