SUSCEPTIBILITY OF SALMONELLA-TYPHI AND BRUCELLA-MELITENSIS TO THE NEWFLUOROQUINOLONE RUFLOXACIN (MF-934)

Authors
QADRI SMH AYUB A UENO Y SALDIN H
Citation
Smh. Qadri et al., SUSCEPTIBILITY OF SALMONELLA-TYPHI AND BRUCELLA-MELITENSIS TO THE NEWFLUOROQUINOLONE RUFLOXACIN (MF-934), Chemotherapy, 39(5), 1993, pp. 311-314
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Oncology
Journal title
Chemotherapy → ACNP
ISSN journal
00093157
Volume
39
Issue
5
Year of publication
1993
Pages
311 - 314
Database
ISI
SICI code
0009-3157(1993)39:5<311:SOSABT>2.0.ZU;2-7
Abstract
The antimicrobial activity of the new fluoroquinolone rufloxacin (MF 9 34) was evaluated by a standardized agar dilution method against recen t clinical isolates of Salmonella typhi (67 strains) and Brucella meli tensis (108 isolates). The results were compared with 5 other commerci ally available or investigational fluoroquinolones. All the isolates o f S. typhi were inhibited by 1.0 mg/l of rufloxacin as compared to 4-8 mg/l for B. melitensis. Minimum inhibitory concentrations of rufloxac in against both S. typhi and B. melitensis were 4-16 times higher than those of other fluoroquinolones.