The flexible and rigid bronchoscopes traverse the nasopharynx or oroph
arynx and carry with them the indigenous microbial flora to distal reg
ions and may thus inoculate the tracheobronchial tree and possibly the
pulmonary parenchyma. The three potential consequences of this event
include: (1) onset of new infection in the tracheobronchial tree or lu
ng parenchyma or, if the patient has preexisting infection, further sp
read of infection locally or to extrapulmonary sites; (2) spread of in
fection from one patient to another via the bronchoscope, if the metho
ds of disinfection and sterilization are inadequate; and (3) pseudoinf
ection due to cross-contamination of the bronchoscope, resulting in is
olation of organisms from the bronchoscopic specimens of a patient who
is clinically not infected. Review of the literature indicates that t
he last-mentioned consequence is more commonly encountered in clinical
practice. The occurrence of pseudoinfection inevitably leads to costl
y and time-consuming procedures to guarantee that the patients are not
infected. Rigorous adherence to sterilization and disinfection proced
ures and a commonsense approach to protecting the uninfected patients
and bronchoscopy personnel from infected patients and instruments will
prevent the risk of propagating infection through the bronchoscope. T
his can be accomplished by establishing a set of policies regarding di
sinfection, sterilization, and protection of uninfected patients, as w
ell as the bronchoscopist and paramedical personnel involved in bronch
oscopy.