A 50-year-old woman with lifelong asthma had nearly total expiratory c
ollapse of her distal trachea. The signs and symptoms were similar to
those of asthma except for a pronounced upper airway component to her
wheezing and the immediate onset of dyspnea on exertion. Surgical repa
ir led to significant improvement in symptoms and resolution of trache
al collapse on expiration. Ultrafast computed tomography was a valuabl
e adjunct to bronchoscopy in diagnosis and management. Expiratory coll
apse of the trachea should be considered in the differential diagnosis
of wheezing and intractable reactive airway disease.