A method of intraoperative procurement of autologous fibrin glue is de
scribed. The relative efficacy of our autologous preparation is compar
ed with that of fibrin glue made with homologous cryoprecipitate. Expe
rimentally, the fibrinogen content and the strength are less than thos
e found in cryoprecipitate and appear related to the fibrinogen conten
t of the autologous plasma used as substrate in the fibrin glue reacti
on. Clinically, no significant differences are noted in the performanc
e of autologous fibrin glue. We believe the absence of the risk of blo
od-borne infection with the autologous product is a major advantage.