A METASTATIC ORTHOTOPIC - TRANSPLANT NUDE-MOUSE MODEL OF HUMAN PATIENT BREAST-CANCER

Authors
FU XY LE PO HOFFMAN RM
Citation
Xy. Fu et al., A METASTATIC ORTHOTOPIC - TRANSPLANT NUDE-MOUSE MODEL OF HUMAN PATIENT BREAST-CANCER, Anticancer research, 13(4), 1993, pp. 901-904
Citations number
20
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
13
Issue
4
Year of publication
1993
Pages
901 - 904
Database
ISI
SICI code
0250-7005(1993)13:4<901:AMO-TN>2.0.ZU;2-Q
Abstract
We report here the development of an orthotopic-transplant model of hu man patient breast cancer in nude mice. Histologically-intact patient breast tumor tissue was transplanted as intact tissue to the mammary f at pad of nude mice where the tumor tissue grew extensively and metast asized to the lung. This is the first orthotopic-transplant metastatic model of human breast cancer. The potential clinical and basic-scienc e uses of the model are discussed.