EFFECTS OF SERINE-PROTEASE INHIBITOR FOY-305 AND HEPARIN ON THE GROWTH OF SQUAMOUS-CELL CARCINOMA

Effects of serine proteinase inhibitor FOY-305 and heparin on autochth onous skin carcinoma were examined using ddY female mice with single t umor induced by methylcholanthrene. FOY-305 given intraperitoneally fo r 9 consecutive weeks inhibited the growth of the pre-existing dermal tumors. Heparin alone was equally therapeutically effective. However, heparin induced severe mucocutaneous bleeding of the gastrointestinal mucosa. In contrast, the combined administration of FOY-305 and hepari n suppressed tumor growth without any visible side effects. There was a significant increase in well differentiated cancer cells in mice tre ated with FOY-305 and heparin in combination, suggesting that co-admin istration of FOY-305 and heparin may be useful for the treatment of sq uamous cell carcinoma.