ASSOCIATION AND DISSOCIATION OF A PROTEASE AND ITS INHIBITOR ON THE SURFACE OF LUNG SQUAMOUS-CELL CARCINOMA-CELLS

Authors
STEVEN FS ANEES M MYERS J HASLETON P
Citation
Fs. Steven et al., ASSOCIATION AND DISSOCIATION OF A PROTEASE AND ITS INHIBITOR ON THE SURFACE OF LUNG SQUAMOUS-CELL CARCINOMA-CELLS, Anticancer research, 13(4), 1993, pp. 1063-1068
Citations number
12
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
13
Issue
4
Year of publication
1993
Pages
1063 - 1068
Database
ISI
SICI code
0250-7005(1993)13:4<1063:AADOAP>2.0.ZU;2-M
Abstract
Squamous cell carcinoma cells possess a cell surface protease, referre d to as guanidinobenzoatase (GB). GB is a plasminogen-activator-like e nzyme which can be located by the fluorescent probe 9-amino acridine i n frozen sections. Fluorescence microscopy has been used to study the inhibition of this GB, the displacement of inhibitor from GB, the disp lacement of GB from the cell surface receptor and the preparation of b oth active GB and inhibitor, obtained from these frozen sections of tu mour tissue.